Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL308293 | 1.00 | P2RX7 (0.38) | P2RX7RORC | |
| SCHEMBL306309 | 0.90 | P2RX7 (0.41) | P2RX7RORC | |
| SCHEMBL308572 | 0.90 | P2RX7 (0.41) | P2RX7RORC | |
| SCHEMBL306616 | 0.88 | P2RX7 (0.43) | P2RX7 | |
| SCHEMBL306615 | 0.88 | P2RX7 (0.43) | P2RX7 | |
| SCHEMBL307036 | 0.88 | P2RX7 (0.36) | P2RX7 | |
| SCHEMBL307035 | 0.88 | P2RX7 (0.36) | P2RX7 | |
| SCHEMBL8135160 | 0.87 | P2RX7 (0.36) | P2RX7 | |
| SCHEMBL308292 | 0.83 | P2RX7 (0.32) | P2RX7 | |
| SCHEMBL306219 | 0.81 | P2RX7 (0.51) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124562-B1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | SECOND GENOME INC (US) | 2016-04-20 | — | — | EP | disclosed |
| US-8093265-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2012-01-10 | — | — | US | disclosed |
| EP-2124562-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008112205-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |