Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307034 | 0.88 | P2RX7 (0.33) | P2RX7 | |
| SCHEMBL306614 | 0.88 | P2RX7 (0.33) | P2RX7 | |
| SCHEMBL308293 | 0.83 | P2RX7 (0.38) | P2RX7 | |
| SCHEMBL308294 | 0.83 | P2RX7 (0.38) | P2RX7 | |
| SCHEMBL306217 | 0.81 | P2RX7 (0.34) | P2RX7 | |
| SCHEMBL305933 | 0.79 | P2RX7 (0.36) | P2RX7 | |
| SCHEMBL306218 | 0.74 | P2RX7 (0.51) | P2RX7 | |
| SCHEMBL306219 | 0.74 | P2RX7 (0.51) | P2RX7 | |
| SCHEMBL4556543 | 0.73 | P2RX7 (0.35) | P2RX7 | |
| SCHEMBL306309 | 0.72 | P2RX7 (0.41) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124562-B1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | SECOND GENOME INC (US) | 2016-04-20 | — | — | EP | disclosed |
| US-8093265-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2012-01-10 | — | — | US | disclosed |
| EP-2124562-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008112205-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |