Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | Q9HBH1 | 1/20 | 0.41 | |
| ▸ | SSTR3 | P32745 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 2/20 | 0.37 |
| ▸ | FURIN | P09958 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PNKP | Q96T60 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL30831347 | 0.85 | FAP (0.42) | PDFSSTR3FURINKMT2AMAP1LC3B | |
| Bicarbonate SCHEMBL30831354 | 0.82 | SMN1; SMN2 (0.36) | SSTR3TGM2ALDH1A1SMN1; SMN2 | |
| SCHEMBL17860166 | 0.81 | FURIN (0.38) | PDFFURINHTTSMN1; SMN2MAP1LC3B | |
| SCHEMBL19776894 | 0.81 | FURIN (0.38) | PDFFURINHTTSMN1; SMN2MAP1LC3B | |
| SCHEMBL23106288 | 0.79 | FURIN (0.38) | FURINKMT2ALMNA | |
| SCHEMBL23106266 | 0.79 | FURIN (0.36) | FURINKMT2AITGB1ITGA4LMNA | |
| SCHEMBL23106135 | 0.79 | FURIN (0.36) | FURINKMT2AITGB1ITGA4LMNA | |
| SCHEMBL19508510 | 0.78 | FURIN (0.39) | PDFFURINALDH1A1MAPTHTT | |
| SCHEMBL22134324 | 0.77 | TAAR1 (0.38) | PDFHTTSMN1; SMN2 | |
| SCHEMBL17860006 | 0.77 | TAAR1 (0.38) | PDFHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117801107-A | Benzazepine derivatives, conjugates containing same and application thereof | 上海迪诺医药科技有限公司 | 2024-04-02 | — | — | CN | disclosed |