Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 4/20 | 0.33 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 7/20 | 0.33 |
| ▸ | HTR2A | P28223 | 5/20 | 0.33 |
| ▸ | HTR2B | P41595 | 5/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3073945 | 0.89 | SSTR4 (0.34) | SSTR4HTR2CSLC6A4MAPTESR2 | |
| SCHEMBL3094904 | 0.85 | MCHR1 (0.38) | MCHR1SLC6A4HRH3 | |
| SCHEMBL3081797 | 0.82 | ESR1 (0.35) | MCHR1SSTR4HTR2CHTR2AHTR2B | |
| SCHEMBL3476357 | 0.78 | SLC6A4 (0.41) | MCHR1SSTR4SSTR1SLC6A4HRH3 | |
| SCHEMBL3476079 | 0.76 | SLC6A2 (0.40) | MCHR1HTR2CSLC6A4GAAMAPT | |
| SCHEMBL3074623 | 0.74 | SSTR4 (0.37) | MCHR1SSTR4SSTR1HTR2CHTR2A | |
| SCHEMBL3079877 | 0.73 | SLC6A2 (0.45) | SSTR4SSTR1HTR2CHTR2AHTR2B | |
| SCHEMBL3096061 | 0.73 | GSK3B (0.43) | MCHR1SSTR4SSTR1SLC6A4DRD2 | |
| SCHEMBL3078965 | 0.72 | ROCK2 (0.43) | — | |
| SCHEMBL3081733 | 0.72 | HTR2C (0.40) | HTR2CHTR2ASLC6A4HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146720-A1 | ARYLOXY-AND HETEROARYLOXY-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR Technology, Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008141082-A1 | ARYLOXY-AND HETEROARYLOXY-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR TECHNOLOGY, INC. (US) | 2008-11-20 | — | — | WO | disclosed |