Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083318 | 0.89 | MCHR1 (0.37) | SSTR4SLC6A4MAPTESR2HTR2C | |
| SCHEMBL3081797 | 0.87 | ESR1 (0.35) | SSTR4SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL3094904 | 0.82 | MCHR1 (0.38) | SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL3477654 | 0.79 | SSTR4 (0.36) | SSTR4SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL3093435 | 0.75 | SSTR4 (0.37) | SSTR4SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL3099039 | 0.74 | SLC6A4 (0.47) | SSTR4SLC6A2SLC6A4SLC6A3MAP4K1 | |
| SCHEMBL3086267 | 0.73 | GSK3B (0.41) | SSTR4SLC6A2SLC6A4SLC6A3MAP4K1 | |
| SCHEMBL3087454 | 0.72 | ROCK2 (0.43) | MAP4K1 | |
| SCHEMBL3079430 | 0.72 | HTR2C (0.39) | SSTR4SLC6A4HTR2C | |
| SCHEMBL3476770 | 0.72 | NOS1 (0.42) | SSTR4SLC6A2SLC6A4SLC6A3MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146720-A1 | ARYLOXY-AND HETEROARYLOXY-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR Technology, Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008141082-A1 | ARYLOXY-AND HETEROARYLOXY-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR TECHNOLOGY, INC. (US) | 2008-11-20 | — | — | WO | disclosed |