Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 2/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16478034 | 0.80 | LMNA (0.38) | LMNAPIK3CGPIK3CDPIK3CAKDM4E | |
| SCHEMBL30309953 | 0.77 | NPC1 (0.41) | LMNAPIK3CGPIK3CDPIK3CAKDM4E | |
| SCHEMBL22027717 | 0.77 | TDP1 (0.47) | LMNAKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL31710911 | 0.77 | NPC1 (0.56) | LMNAKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5310147 | 0.69 | AHR (0.50) | LMNAKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31351998 | 0.65 | LMNA (0.51) | LMNAKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5435763 | 0.64 | APOBEC3A (0.53) | PIK3CGPIK3CDPIK3CA | |
| SCHEMBL30827999 | 0.64 | BRAF (0.34) | ATR | |
| SCHEMBL24198306 | 0.63 | ATR (0.42) | ATR | |
| SCHEMBL24198153 | 0.63 | ATR (0.47) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3947375-B1 | IMIDAZOLONYLQUINOLINE COMPOUNDS AND THERAPEUTIC USES THEREOF | MERCK PATENT GMBH (DE) | 2024-04-03 | — | — | EP | claimed |