Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29190564 | 0.81 | MAPK1 (0.44) | AXLPDPK1GSK3BFGFR1FGFR2 | |
| SCHEMBL30833712 | 0.81 | MAPK1 (0.44) | AXLPDPK1GSK3BFGFR1FGFR2 | |
| SCHEMBL30833670 | 0.78 | HTT (0.54) | SIGMAR1LMNA | |
| SCHEMBL4785556 | 0.77 | AXL (0.50) | AXLAURKBJAK2MAPK1KMT2A | |
| SCHEMBL30833725 | 0.77 | AXL (0.50) | AXLAURKBJAK2MAPK1KMT2A | |
| SCHEMBL29190556 | 0.74 | MAPK1 (0.54) | AXLPDPK1JAK2MAPK1 | |
| SCHEMBL29190522 | 0.72 | KCNH2 (0.44) | AXLAURKBFGFR1JAK2PIM1 | |
| SCHEMBL30833743 | 0.72 | KCNH2 (0.44) | AXLAURKBFGFR1JAK2PIM1 | |
| SCHEMBL29190529 | 0.71 | AXL (0.44) | AXLPDPK1GSK3BAURKBJAK2 | |
| SCHEMBL922069 | 0.68 | PDPK1 (0.65) | AXLPDPK1AURKBFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |