Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29190522 | 1.00 | KCNH2 (0.44) | KCNH2AXLHTR1DHTR1BMAPK1 | |
| SCHEMBL30833725 | 0.87 | AXL (0.50) | AXLMAPK1JAK2AURKBCDK2 | |
| SCHEMBL4785556 | 0.87 | AXL (0.50) | AXLMAPK1JAK2AURKBCDK2 | |
| SCHEMBL29190689 | 0.86 | MAPK1 (0.44) | KCNH2AXLMAPK1JAK2FGFR1 | |
| SCHEMBL30833762 | 0.86 | MAPK1 (0.44) | KCNH2AXLMAPK1JAK2FGFR1 | |
| SCHEMBL29190644 | 0.81 | MEN1 (0.41) | KCNH2MAPK1 | |
| SCHEMBL30833752 | 0.81 | MEN1 (0.41) | KCNH2MAPK1 | |
| SCHEMBL4785792 | 0.77 | JAK2 (0.54) | AXLHTR1DHTR1BMAPK1JAK2 | |
| SCHEMBL29190529 | 0.76 | AXL (0.44) | AXLMAPK1JAK2AURKBCDK2 | |
| SCHEMBL29190556 | 0.74 | MAPK1 (0.54) | AXLMAPK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |