Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26709323 | 0.91 | ABL1 (0.40) | CCNE2CCNE1CDK2ABL1SRC | |
| SCHEMBL30835154 | 0.91 | ABL1 (0.40) | CCNE2CCNE1CDK2ABL1SRC | |
| SCHEMBL28561177 | 0.73 | PPARG (0.59) | CCNE2CCNE1CDK2ABL1SRC | |
| SCHEMBL31278716 | 0.72 | NPC1 (0.41) | CCNE2CCNE1CDK2ABL1SRC | |
| SCHEMBL31279002 | 0.72 | NPC1 (0.41) | CCNE2CCNE1CDK2ABL1SRC | |
| SCHEMBL25247825 | 0.70 | L3MBTL1 (0.36) | L3MBTL1MEN1ALDH1A1MAPTRECQL | |
| SCHEMBL25217957 | 0.69 | CYP1A2 (0.30) | KMT2A | |
| SCHEMBL28202910 | 0.69 | CLK4 (0.47) | ABL1SRCL3MBTL1MEN1MAPT | |
| SCHEMBL15619030 | 0.68 | CCNE2 (0.68) | CCNE2CCNE1CDK2L3MBTL1MAPT | |
| SCHEMBL3116066 | 0.68 | POLB (0.71) | ABL1SRCALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119790059-A | Heterocyclic compounds as KRAS inhibitors, their preparation and therapeutic use | 上海科州药物股份有限公司 | 2025-04-08 | — | — | CN | disclosed |
| CN-117813306-A | Heterocyclic compounds as KRAS inhibitors, their preparation and therapeutic use | 上海科州药物研发有限公司 | 2024-04-02 | — | — | CN | disclosed |