Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.68 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.68 |
| ▸ | CDK2 | P24941 | 1/20 | 0.68 |
| ▸ | PRUNE1 | Q86TP1 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3108534 | 0.84 | CCNE2 (0.61) | CCNE2CCNE1CDK2PRUNE1HTT | |
| SCHEMBL3114875 | 0.84 | CCNE2 (0.55) | CCNE2CCNE1CDK2HTTPDE5A | |
| SCHEMBL3108353 | 0.83 | CCNE2 (0.54) | CCNE2CCNE1CDK2HTTPIK3CA | |
| SCHEMBL2801822 | 0.82 | PIK3CA (0.66) | CCNE2CCNE1CDK2PIK3CAAPP | |
| SCHEMBL5888965 | 0.82 | PIK3CA (0.62) | CCNE2CCNE1CDK2PIK3CAAPP | |
| SCHEMBL7973136 | 0.82 | CCNE2 (0.58) | CCNE2CCNE1CDK2CDK1PDE5A | |
| SCHEMBL22411468 | 0.81 | CCNE2 (0.52) | CCNE2CCNE1CDK2PRUNE1HTT | |
| SCHEMBL30747798 | 0.81 | CCNE2 (0.77) | CCNE2CCNE1CDK2TDP1CDK1 | |
| SCHEMBL27249486 | 0.81 | CCNE2 (0.77) | CCNE2CCNE1CDK2TDP1CDK1 | |
| SCHEMBL29019899 | 0.81 | CCNE2 (0.57) | CCNE2CCNE1CDK2HTTPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014045310-A1 | PYRIMIDO[5,4-D]PYRIMIDINE OR PYRIMIDINE DERIVATIVES COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | ZOLLO MASSIMO (IT) | 2014-03-27 | — | — | WO | disclosed |
| WO-2014045310-A1 | PYRIMIDO[5,4-D]PYRIMIDINE OR PYRIMIDINE DERIVATIVES COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | ZOLLO MASSIMO (IT) | 2014-03-27 | — | — | WO | disclosed |