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Sugi Predict / Compounds / SCHEMBL30836458

SCHEMBL30836458

SCHEMBL30836458

COc1cc(-c2nccc(-c3cccc(NC(=O)c4ccc(CN(C)CCO)cn4)c3C)c2Cl)ccc1CNC1CCN(C(C)=O)CC1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ CD274 Q9NZQ7 20/20 0.53
▸ PDCD1 Q15116 19/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27081043 0.94 CD274 (0.46) CD274PDCD1
SCHEMBL27079039 0.92 CD274 (0.51) CD274PDCD1
SCHEMBL29983642 0.91 CD274 (0.43) CD274PDCD1
SCHEMBL27078771 0.90 CD274 (0.54) CD274PDCD1
SCHEMBL29983091 0.90 CD274 (0.54) CD274PDCD1
SCHEMBL30836557 0.90 CD274 (0.50) CD274PDCD1
SCHEMBL30836612 0.90 CD274 (0.45) CD274PDCD1
SCHEMBL27080215 0.90 CD274 (0.43) CD274PDCD1
SCHEMBL29144038 0.87 CD274 (0.51) CD274PDCD1
SCHEMBL27079293 0.87 CD274 (0.48) CD274PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024069448-A1 SUBSTITUTED 1-ARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1-HETEROARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2024-04-04 — — WO claimed
WO-2024069448-A1 SUBSTITUTED 1-ARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1-HETEROARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2024-04-04 — — WO disclosed
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