Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 3/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12505661 | 0.76 | ADRA1A (0.48) | ADRA1AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL4977111 | 0.75 | ADRA1A (0.45) | ADRA1AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL28212021 | 0.73 | ADRA1A (0.51) | ADRA1AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL6383642 | 0.73 | ADRA1A (0.51) | ADRA1AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL161548 | 0.73 | ADRA1A (0.51) | ADRA1AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL28197915 | 0.73 | ADRA1A (0.46) | ADRA1AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL21590354 | 0.73 | JAK1 (0.43) | ADRA1AALDH1A1KDM4EMAPTHPGD | |
| Hydrochloric Acid SCHEMBL30170745 | 0.72 | ADRA1A (0.50) | ADRA1AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL4429354 | 0.71 | SLC6A2 (0.32) | ALDH1A1KDM4EHPGDHSD17B10GLA | |
| SCHEMBL34473815 | 0.71 | ADRA1A (0.47) | ADRA1AALDH1A1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240082223-A1 | DIHYDROFUROPYRIDINE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2024-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240082223-A1 | DIHYDROFUROPYRIDINE DERIVATIVES AS RHO- KINASE INHIBITORS | ROCK1, ROCK2, RHOA | ADRA1A 459/4885ALDH1A1 1029/4885KDM4E 899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.