Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27285033 | 0.99 | TRPA1 (0.35) | TRPA1DRD1 | |
| Iodide SCHEMBL30841178 | 0.82 | TRPA1 (0.34) | TRPA1DRD1 | |
| SCHEMBL31625892 | 0.82 | KDM4E (0.38) | TRPA1 | |
| SCHEMBL27275538 | 0.82 | KDM4E (0.38) | TRPA1 | |
| Iodide SCHEMBL30840584 | 0.82 | RHEB (0.34) | TRPA1 | |
| SCHEMBL27285201 | 0.81 | PRKCI (0.38) | TRPA1DRD1 | |
| SCHEMBL27285206 | 0.81 | ASH1L (0.36) | TRPA1DRD1 | |
| SCHEMBL27285111 | 0.81 | TRPA1 (0.35) | TRPA1DRD1 | |
| SCHEMBL30840025 | 0.81 | TRPA1 (0.35) | TRPA1DRD1 | |
| SCHEMBL27276624 | 0.81 | RHEB (0.35) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4583972-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | Sionna Therapeutics Inc. (US) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024054840-A1 | MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF | SIONNA THERAPEUTICS (US) | 2024-03-14 | — | — | WO | disclosed |