Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29207319 | 0.85 | CHRNB2 (0.35) | MEN1ALDH1A1KMT2AUSP2 | |
| SCHEMBL30841276 | 0.83 | USP2 (0.41) | NR1H2MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL31094705 | 0.83 | USP2 (0.41) | NR1H2MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL656014 | 0.82 | DDB1 (0.44) | NR1H2DDB1CRBNMEN1ALDH1A1 | |
| SCHEMBL30841148 | 0.80 | USP2 (0.39) | NR1H2MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL31424868 | 0.77 | MEN1 (0.45) | NR1H2DDB1CRBNMEN1ALDH1A1 | |
| SCHEMBL16825886 | 0.74 | DDB1 (0.43) | NR1H2DDB1CRBNMEN1ALDH1A1 | |
| SCHEMBL31339121 | 0.73 | NR1H2 (0.49) | NR1H2DDB1CRBNMEN1ALDH1A1 | |
| SCHEMBL25845322 | 0.73 | NR1H2 (0.44) | NR1H2DDB1CRBNMEN1ALDH1A1 | |
| SCHEMBL28845330 | 0.72 | DDB1 (0.43) | NR1H2DDB1CRBNMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024067714-A1 | COMPOUNDS WITH ANTI-KRAS MUTANT TUMOR ACTIVITY | 泰励生物科技（上海）有限公司 | 2024-04-04 | — | — | WO | disclosed |
| CN-117800975-A | Compounds with anti-KRAS mutant tumor activity | 泰励生物科技（上海）有限公司 | 2024-04-02 | — | — | CN | disclosed |