Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033171 | 0.88 | HRH4 (0.52) | HRH4HRH3CHEK1KDM4ENPC1 | |
| SCHEMBL30845792 | 0.84 | KDM4E (0.53) | KDM4EHTTNPC1RAB9ALMNA | |
| SCHEMBL21033293 | 0.82 | KDM4E (0.55) | HRH4HRH3KDM4ENPC1RAB9A | |
| SCHEMBL8065354 | 0.75 | TGFBR1 (0.50) | HRH4HRH3KDM4ENPC1RAB9A | |
| SCHEMBL21033169 | 0.74 | PTGS1 (0.50) | HRH4HRH3KDM4ENPC1RAB9A | |
| SCHEMBL30845741 | 0.71 | EGLN1 (0.52) | HRH4HRH3CHEK1PIM1KDM4E | |
| SCHEMBL17512464 | 0.71 | TGFBR1 (0.44) | HRH4HRH3KDM4ENPC1RAB9A | |
| SCHEMBL16104299 | 0.71 | CLK1 (0.55) | HRH4HRH3KDM4EALDH1A1MAPT | |
| SCHEMBL21033175 | 0.71 | KDM4E (0.54) | KDM4ENPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL21033712 | 0.71 | KDM4E (0.60) | KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |