Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033175 | 0.88 | KDM4E (0.54) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL30845773 | 0.84 | HRH4 (0.51) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL19736708 | 0.81 | KDM4E (0.54) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL3368805 | 0.79 | RAB9A (0.76) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL27037204 | 0.76 | SLC2A1 (0.45) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL19736936 | 0.76 | MAPT (0.48) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL21396314 | 0.75 | NPC1 (0.53) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL19736940 | 0.75 | PIK3R1 (0.44) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL30828891 | 0.75 | METTL3 (0.40) | MAPTPIK3CAMTORSYKEGLN1 | |
| SCHEMBL8065354 | 0.75 | TGFBR1 (0.50) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |