Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 5/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.43 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033596 | 0.90 | PIK3CG (0.51) | GRM2PIK3CGIRAK4CCNCCDK8 | |
| SCHEMBL21033576 | 0.82 | KDM4E (0.60) | PIK3CGFYNCHEK1RIPK1 | |
| SCHEMBL21033570 | 0.78 | FYN (0.42) | PIK3CGFYNCHEK1RIPK1GRK5 | |
| SCHEMBL30845750 | 0.77 | KDM4E (0.38) | CDK8CSNK1DCSNK1E | |
| SCHEMBL29908155 | 0.76 | USP30 (0.54) | GRM2PIK3CGCCNCCDK8MKNK1 | |
| SCHEMBL30828852 | 0.75 | GRM2 (0.44) | GRM2IRAK4CCNCCDK8FYN | |
| SCHEMBL29502453 | 0.75 | IRAK4 (0.67) | GRM2IRAK4CCNCCDK8CHEK1 | |
| SCHEMBL22835312 | 0.75 | IRAK4 (0.67) | GRM2IRAK4CCNCCDK8CHEK1 | |
| SCHEMBL30845759 | 0.75 | GRM2 (0.47) | GRM2PIK3CGIRAK4CCNCCDK8 | |
| SCHEMBL21639192 | 0.73 | AHR (0.50) | CDK8FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |