Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | S100A4 | P26447 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12458500 | 1.00 | MEN1 (0.45) | MEN1KMT2APOLBS100A4ALDH1A1 | |
| SCHEMBL18053325 | 1.00 | MEN1 (0.45) | MEN1KMT2APOLBS100A4ALDH1A1 | |
| SCHEMBL7915228 | 0.72 | MEN1 (0.48) | MEN1KMT2APOLBS100A4ALDH1A1 | |
| SCHEMBL21208080 | 0.68 | CRBN (0.58) | ALDH1A1CYP1A2TDP1 | |
| SCHEMBL86112 | 0.67 | KMT2A (0.48) | MEN1KMT2APOLBS100A4ALDH1A1 | |
| SCHEMBL10287951 | 0.67 | MEN1 (0.48) | MEN1KMT2APOLBS100A4ALDH1A1 | |
| SCHEMBL8365427 | 0.67 | ALDH1A1 (0.58) | MEN1KMT2APOLBS100A4ALDH1A1 | |
| Anthraquinone SCHEMBL14723446 | 0.67 | TDP1 (0.48) | MEN1KMT2APOLBS100A4ALDH1A1 | |
| SCHEMBL78821 | 0.67 | CYP2C9 (0.68) | MEN1KMT2AALDH1A1MAPTDHFR | |
| SCHEMBL38819 | 0.67 | CYP2C9 (0.68) | MEN1KMT2AALDH1A1MAPTDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |