Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21001703 | 0.87 | HDAC6 (0.38) | HRH3HDAC6MGLLKCNH2SMO | |
| SCHEMBL31125632 | 0.80 | NAMPT (0.44) | NAMPTHDAC6LTA4HGRM2MEN1 | |
| SCHEMBL21033498 | 0.80 | SMO (0.47) | SMOKMT2AALDH1A1POLB | |
| SCHEMBL16387227 | 0.74 | P2RX7 (0.40) | HRH3ALDH1A1 | |
| SCHEMBL26021697 | 0.71 | P2RX7 (0.40) | ALDH1A1 | |
| SCHEMBL4090031 | 0.70 | HDAC1 (0.50) | NAMPTLTA4HKMT2AALDH1A1MAPT | |
| SCHEMBL15933428 | 0.69 | HDAC2 (0.51) | NAMPTLTA4HMGLLGRM2 | |
| SCHEMBL30845765 | 0.69 | GRM2 (0.35) | NAMPTLTA4HGRM2ALDH1A1MAPT | |
| SCHEMBL31125699 | 0.68 | HDAC6 (0.36) | HRH3HDAC6PARP1KCNH2 | |
| SCHEMBL3308376 | 0.66 | HDAC6 (0.41) | NAMPTHDAC6MGLLSMOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |