Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 5/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19876673 | 0.86 | USP2 (0.40) | LMNARIPK1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL30845763 | 0.79 | ALDH1A1 (0.39) | NAMPTALDH1A1LMNAMAP3K14RIPK1 | |
| SCHEMBL21033474 | 0.79 | GABRA2 (0.42) | ALDH1A1SMN1; SMN2HPGDKDM4EMAPT | |
| SCHEMBL30845770 | 0.76 | HDAC2 (0.38) | GRM2NR1I2NAMPTLMNAMAP3K14 | |
| SCHEMBL24493227 | 0.74 | P2RX7 (0.33) | ALDH1A1LMNASMN1; SMN2HPGDKDM4E | |
| SCHEMBL31125632 | 0.72 | NAMPT (0.44) | GRM2NAMPTALDH1A1CDK8MAP3K14 | |
| SCHEMBL4090031 | 0.71 | HDAC1 (0.50) | NAMPTALDH1A1LMNASMN1; SMN2LTA4H | |
| SCHEMBL15933428 | 0.70 | HDAC2 (0.51) | GRM2NAMPTLTA4H | |
| SCHEMBL30845858 | 0.69 | NAMPT (0.42) | GRM2NAMPTALDH1A1MAP3K14LTA4H | |
| SCHEMBL21570164 | 0.68 | RIPK1 (0.34) | LMNARIPK1HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |