Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 6/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27126473 | 1.00 | TDP1 (0.41) | TDP1SLC40A1MMP2NAMPTLMNA | |
| SCHEMBL27125948 | 0.84 | TDP1 (0.41) | TDP1SLC40A1MMP2LMNAMAPK1 | |
| SCHEMBL30846365 | 0.84 | SLC40A1 (0.41) | TDP1SLC40A1MMP2NAMPTLMNA | |
| SCHEMBL27126476 | 0.84 | SLC40A1 (0.41) | TDP1SLC40A1MMP2NAMPTLMNA | |
| SCHEMBL30846193 | 0.83 | GAA (0.55) | TDP1SLC40A1LMNAMAPK1GAA | |
| SCHEMBL27123592 | 0.83 | GAA (0.55) | TDP1SLC40A1LMNAMAPK1GAA | |
| SCHEMBL27125153 | 0.82 | L3MBTL1 (0.40) | TDP1SLC40A1NAMPTSLC16A3ALDH1A1 | |
| SCHEMBL30846304 | 0.82 | L3MBTL1 (0.40) | TDP1SLC40A1NAMPTSLC16A3ALDH1A1 | |
| SCHEMBL30846268 | 0.82 | TDP1 (0.36) | TDP1SLC40A1LMNAMAPK1GAA | |
| SCHEMBL27154166 | 0.82 | TDP1 (0.36) | TDP1SLC40A1LMNAMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044344-A1 | PYRIDINYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |