Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.72 |
| ▸ | IDH2 | P48735 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | KIF11 | P52732 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | CLK2 | P49760 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CTSC | P53634 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27110454 | 1.00 | AURKA (0.72) | AURKAIDH2KDM4EKIF11FLT1 | |
| SCHEMBL31501743 | 0.83 | AURKA (0.72) | AURKAIDH2KDM4EKIF11LMNA | |
| SCHEMBL6663767 | 0.83 | AURKA (0.72) | AURKAIDH2KDM4EKIF11LMNA | |
| SCHEMBL2113984 | 0.83 | AURKA (0.77) | AURKAIDH2KDM4EMAPK8CTSC | |
| SCHEMBL14088796 | 0.83 | AURKA (0.72) | AURKAIDH2KDM4EKIF11FLT1 | |
| SCHEMBL84379 | 0.82 | AURKA (0.67) | AURKAIDH2KDM4EKIF11FLT1 | |
| SCHEMBL5732656 | 0.79 | AURKA (0.66) | AURKAIDH2KDM4EFLT1FLT4 | |
| SCHEMBL4901590 | 0.79 | ABL1 (0.67) | AURKAIDH2KDM4EKIF11FLT1 | |
| SCHEMBL4140858 | 0.78 | CTSC (0.67) | AURKAIDH2KDM4EKDRSYK | |
| SCHEMBL3601052 | 0.78 | HDAC3 (0.67) | AURKAIDH2KDM4EKIF11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |