Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.47 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27112980 | 1.00 | MAPK1 (0.65) | MAPK1HTTALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL338139 | 0.87 | ALDH1A1 (0.68) | MAPK1HTTALDH1A1HSD17B10PDE10A | |
| SCHEMBL31144716 | 0.84 | ALDH1A1 (0.52) | MAPK1HTTALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL1104809 | 0.83 | HTT (0.69) | MAPK1HTTALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL10818841 | 0.83 | PDE10A (0.54) | MAPK1HTTALDH1A1CYP1A2PDE10A | |
| SCHEMBL13916684 | 0.83 | HTT (0.72) | MAPK1HTTALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL18314223 | 0.83 | ESR1 (0.54) | MAPK1HTTHSD17B10CYP1A2KDM4E | |
| SCHEMBL13916683 | 0.81 | HTT (0.70) | MAPK1HTTALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL1104832 | 0.81 | MAPK1 (0.65) | MAPK1HTTALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL14247592 | 0.81 | HCAR1 (0.47) | MAPK1HTTALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |