Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22980753 | 0.77 | L3MBTL1 (0.47) | TTKBRD4 | |
| SCHEMBL22990805 | 0.76 | USP30 (0.51) | — | |
| SCHEMBL28875389 | 0.74 | PAX8 (0.39) | TTKBRD4PAX8HTR2CSLC6A4 | |
| SCHEMBL12903453 | 0.73 | BRD4 (0.46) | BRD4PAX8 | |
| SCHEMBL18354216 | 0.73 | TTK (0.34) | TTKBRD4PAX8 | |
| SCHEMBL16629271 | 0.73 | BRD4 (0.38) | TTKBRD4PAX8HTR2CSLC6A4 | |
| SCHEMBL22981473 | 0.71 | PAX8 (0.37) | TTKBRD4PAX8 | |
| SCHEMBL31453184 | 0.70 | PAX8 (0.38) | TTKBRD4PAX8HTR2CSLC6A4 | |
| SCHEMBL22029019 | 0.70 | XPO1 (0.48) | PAX8 | |
| SCHEMBL8232361 | 0.70 | NCEH1 (0.40) | TTKBRD4PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598901-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | Thomas Jefferson University (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076964-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-04-11 | — | — | WO | disclosed |