Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 4/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25994275 | 1.00 | CDK1 (0.45) | CDK1ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL24148858 | 0.84 | BCHE (0.39) | CDK1BCHEGABRA1GABRG2GABRB3 | |
| SCHEMBL6137318 | 0.82 | CDK1 (0.42) | CDK1ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL23959057 | 0.81 | CDK1 (0.46) | CDK1ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL31274704 | 0.81 | BCHE (0.52) | CDK1BCHE | |
| SCHEMBL26628082 | 0.81 | BCHE (0.52) | CDK1BCHE | |
| SCHEMBL5233322 | 0.76 | USP30 (0.36) | CDK1ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL31499359 | 0.74 | CDK1 (0.46) | CDK1BCHEBACE1ROCK2CCNB2 | |
| SCHEMBL23959044 | 0.73 | CDK1 (0.46) | CDK1TSHRUSP30BCHEGABRA1 | |
| SCHEMBL12813131 | 0.72 | BCHE (0.64) | CDK1KMT2AMEN1USP30BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024064316-A1 | COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 INHIBITORS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-03-28 | — | — | WO | disclosed |