Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 6/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30847767 | 0.91 | POLQ (0.39) | POLQDRD3DRD2TACR1KCNH2 | |
| SCHEMBL30847713 | 0.89 | POLQ (0.41) | POLQDRD3DRD2TACR1P2RX7 | |
| SCHEMBL30847630 | 0.88 | DRD3 (0.39) | POLQDRD3DRD2TACR1KCNH2 | |
| SCHEMBL30847735 | 0.86 | POLQ (0.38) | POLQDRD3DRD2TACR1P2RX7 | |
| SCHEMBL30847729 | 0.86 | POLQ (0.38) | POLQDRD3DRD2TACR1P2RX7 | |
| SCHEMBL30847683 | 0.85 | POLQ (0.38) | POLQTACR1P2RX7 | |
| SCHEMBL30847774 | 0.85 | POLQ (0.41) | POLQTACR1P2RX7 | |
| SCHEMBL30847786 | 0.85 | POLQ (0.39) | POLQTACR1SCN9AP2RX7HDAC1 | |
| SCHEMBL30847546 | 0.84 | POLQ (0.37) | POLQ | |
| SCHEMBL30847678 | 0.84 | POLQ (0.43) | POLQDRD3DRD2P2RX7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598901-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | Thomas Jefferson University (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076964-A1 | PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-04-11 | — | — | WO | disclosed |