Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | DDX3X | O00571 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27132536 | 1.00 | RXRA (0.44) | RXRAGRIN1GRIN2BNOTUMDDX3X | |
| SCHEMBL30848041 | 0.87 | RXRA (0.38) | RXRAGRIN1GRIN2BCYP3A4CHRM4 | |
| SCHEMBL27132346 | 0.87 | RXRA (0.38) | RXRAGRIN1GRIN2BCYP3A4CHRM4 | |
| SCHEMBL27132541 | 0.86 | RXRA (0.36) | RXRAGRIN1GRIN2BSLC40A1AR | |
| SCHEMBL30847925 | 0.86 | RXRA (0.36) | RXRAGRIN1GRIN2BSLC40A1AR | |
| SCHEMBL30847942 | 0.84 | SLC40A1 (0.32) | RXRAGRIN1GRIN2BSLC40A1AR | |
| SCHEMBL27132539 | 0.84 | SLC40A1 (0.32) | RXRAGRIN1GRIN2BSLC40A1AR | |
| SCHEMBL27132597 | 0.81 | RXRA (0.35) | RXRAGRIN1GRIN2BDDX3XCHRM4 | |
| SCHEMBL30847769 | 0.81 | RXRA (0.35) | RXRAGRIN1GRIN2BDDX3XCHRM4 | |
| SCHEMBL30847962 | 0.81 | GAA (0.32) | RXRAGRIN1GRIN2BSLC40A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577536-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | Hotspot Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |