Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27132351 | 1.00 | RXRA (0.33) | RXRAGRIN1GRIN2BPTGS2PTGS1 | |
| SCHEMBL27132783 | 0.88 | RXRA (0.36) | RXRAGRIN1GRIN2BPTGS2AR | |
| SCHEMBL30848042 | 0.88 | RXRA (0.36) | RXRAGRIN1GRIN2BPTGS2AR | |
| SCHEMBL27132346 | 0.87 | RXRA (0.38) | RXRAGRIN1GRIN2BPTGS2PTGS1 | |
| SCHEMBL30848041 | 0.87 | RXRA (0.38) | RXRAGRIN1GRIN2BPTGS2PTGS1 | |
| SCHEMBL27132348 | 0.86 | SLC40A1 (0.38) | RXRAGRIN1GRIN2BPTGS2PTGS1 | |
| SCHEMBL30847993 | 0.86 | SLC40A1 (0.38) | RXRAGRIN1GRIN2BPTGS2PTGS1 | |
| SCHEMBL30847954 | 0.85 | SCN9A (0.33) | RXRAGRIN1GRIN2BAROXTR | |
| SCHEMBL27132405 | 0.85 | SCN9A (0.33) | RXRAGRIN1GRIN2BAROXTR | |
| SCHEMBL30847936 | 0.84 | CYP17A1 (0.38) | RXRAGRIN1GRIN2BCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577536-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | Hotspot Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |