Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.33 |
| ▸ | AXL | P30530 | 3/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.33 |
| ▸ | MERTK | Q12866 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | SCN1A | P35498 | 2/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | UGCG | Q16739 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27132716 | 1.00 | RXRA (0.34) | RXRAGRIN1GRIN2BSCN9AAXL | |
| SCHEMBL27132406 | 0.89 | RXRA (0.37) | RXRAGRIN1GRIN2BSCN9A | |
| SCHEMBL30847861 | 0.89 | RXRA (0.37) | RXRAGRIN1GRIN2BSCN9A | |
| SCHEMBL30847993 | 0.89 | SLC40A1 (0.38) | RXRAGRIN1GRIN2BSCN9A | |
| SCHEMBL27132348 | 0.89 | SLC40A1 (0.38) | RXRAGRIN1GRIN2BSCN9A | |
| SCHEMBL30848028 | 0.87 | SCN9A (0.34) | RXRAGRIN1GRIN2BSCN9ALRRK2 | |
| SCHEMBL27132407 | 0.87 | SCN9A (0.34) | RXRAGRIN1GRIN2BSCN9ALRRK2 | |
| SCHEMBL27132783 | 0.86 | RXRA (0.36) | RXRAGRIN1GRIN2BSCN9ACHRM4 | |
| SCHEMBL30848042 | 0.86 | RXRA (0.36) | RXRAGRIN1GRIN2BSCN9ACHRM4 | |
| SCHEMBL30847936 | 0.86 | CYP17A1 (0.38) | RXRAGRIN1GRIN2BSCN9ACHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577536-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | Hotspot Therapeutics, Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |