Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 8/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | PRKCB | P05771 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30848448 | 0.90 | HTR6 (0.37) | NPC1HTR6DGAT1EGFRIGF1R | |
| SCHEMBL19260864 | 0.84 | DGAT1 (0.34) | NPC1DGAT1EGFRIGF1RSRC | |
| SCHEMBL31050029 | 0.83 | DGAT1 (0.40) | NPC1HTR6DGAT1EGFRIGF1R | |
| SCHEMBL15533247 | 0.82 | EGFR (0.34) | NPC1DGAT1EGFRIGF1RSRC | |
| SCHEMBL21044790 | 0.82 | DGAT1 (0.41) | NPC1HTR6DGAT1EGFRIGF1R | |
| SCHEMBL29748840 | 0.82 | DGAT1 (0.41) | NPC1HTR6DGAT1EGFRIGF1R | |
| SCHEMBL30168284 | 0.80 | NPC1 (0.46) | NPC1CNR1CNR2 | |
| SCHEMBL29514362 | 0.79 | ELANE (0.47) | — | |
| SCHEMBL15546774 | 0.79 | POLB (0.39) | NPC1DGAT1EGFRIGF1RSRC | |
| SCHEMBL25001937 | 0.78 | CNR1 (0.45) | NPC1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024064335-A1 | NAPHTHYL-SUBSTITUTED PYRANOPYRIMIDINONES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Ikena Oncology, Inc. (US) | 2024-03-28 | — | — | WO | disclosed |