Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30164510 | 0.88 | USP2 (0.35) | USP2SMN1; SMN2GPR119GRM5USP30 | |
| SCHEMBL15785128 | 0.80 | GPR119 (0.39) | GPR119NR1H2USP30PDK4 | |
| SCHEMBL21135638 | 0.79 | NR1H2 (0.41) | USP2SMN1; SMN2KDM4EGPR119MAPT | |
| SCHEMBL19759343 | 0.79 | NR1H2 (0.41) | USP2SMN1; SMN2KDM4EGPR119MAPT | |
| SCHEMBL31214052 | 0.78 | USP2 (0.36) | USP2SMN1; SMN2KDM4EGPR119MAPT | |
| SCHEMBL16052667 | 0.77 | USP30 (0.40) | USP2SMN1; SMN2KDM4EGPR119MAPT | |
| SCHEMBL16052666 | 0.77 | USP30 (0.40) | USP2SMN1; SMN2KDM4EGPR119MAPT | |
| SCHEMBL10181219 | 0.77 | RORC (0.38) | KDM4EGPR119USP30PDK4 | |
| SCHEMBL31363968 | 0.75 | NPSR1 (0.53) | SMN1; SMN2KDM4EMAPTGRM5PDK4 | |
| SCHEMBL25047623 | 0.75 | PDK4 (0.39) | USP2SMN1; SMN2KDM4EGPR119MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117916232-A | Heterocyclic EGFR inhibitors for the treatment of cancer | 缆图药品公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117858872-A | Heterocyclic EGFR inhibitors for the treatment of cancer | 缆图药品公司 | 2024-04-09 | — | — | CN | disclosed |