Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | KCNB1 | Q14721 | 7/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216527 | 0.81 | EGFR (0.52) | EGFRPDPK1KCNB1KCNA5ADRB2 | |
| SCHEMBL4355764 | 0.79 | PDPK1 (0.55) | EGFRPDPK1ADRB2LOXL2CYP2A6 | |
| SCHEMBL15606528 | 0.79 | PDPK1 (0.58) | EGFRPDPK1ADRB2LOXL2CYP2A6 | |
| SCHEMBL13994026 | 0.78 | PDPK1 (0.50) | EGFRPDPK1KCNB1KCNA5ADRB2 | |
| SCHEMBL2152506 | 0.77 | NOTUM (0.57) | EGFRPDPK1LOXL2CYP2A6NPC1 | |
| SCHEMBL8078445 | 0.76 | EGFR (0.47) | EGFRPDPK1KCNB1ADRB2LOXL2 | |
| SCHEMBL15805858 | 0.75 | PDPK1 (0.72) | EGFRPDPK1ADRB2LOXL2CYP2A6 | |
| SCHEMBL18313516 | 0.73 | PDPK1 (0.59) | EGFRPDPK1KCNB1ADRB2LOXL2 | |
| SCHEMBL2654169 | 0.72 | PDPK1 (0.50) | EGFRPDPK1ADRB2LOXL2CYP2A6 | |
| SCHEMBL4452723 | 0.71 | PDPK1 (0.53) | PDPK1KCNB1CYP2A6NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598912-A1 | POLO LIKE KINASE 4 INHIBITORS | Oric Pharmaceuticals, Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076891-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. (US) | 2024-04-11 | — | — | WO | disclosed |