Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 7/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.58 |
| ▸ | PDE4A | P27815 | 3/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.51 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6555067 | 0.85 | ADORA2B (0.57) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL8884694 | 0.85 | ADORA2B (0.61) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL7491449 | 0.81 | ADORA2B (0.56) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL7800909 | 0.79 | ADORA2B (0.50) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL618977 | 0.77 | ADORA2B (0.64) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL18285098 | 0.77 | ADORA2A (0.55) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL8952223 | 0.77 | ADORA2A (0.55) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL11572222 | 0.76 | ADORA2B (0.59) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL28403443 | 0.76 | ADORA2B (0.62) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| 1-Methylxanthine SCHEMBL7270651 | 0.74 | ADORA2B (0.77) | ADORA2BADORA2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180055868-A1 | METHODS AND COMPOSITIONS FOR STIMULATING BONE REGENERATION | NEW YORK UNIVERSITY (US) | 2018-03-01 | — | — | US | disclosed |
| US-20160262894-A1 | TISSUE REPAIR DEVICES AND SCAFFOLDS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2016-09-15 | — | — | US | disclosed |
| WO-2015065819-A1 | TISSUE REPAIR DEVICES AND SCAFFOLDS | NEW YORK UNIVERSITY (US) | 2015-05-07 | — | — | WO | disclosed |
| US-20150011496-A1 | METHODS AND COMPOSITIONS FOR STIMULATING BONE REGENERATION | NEW YORK UNIVERSITY | 2015-01-08 | — | — | US | disclosed |
| WO-2013126545-A1 | METHODS AND COMPOSITIONS FOR STIMULATING BONE REGENERATION | NEW YORK UNIVERSITY (US) | 2013-08-29 | — | — | WO | disclosed |
| US-7795427-B2 | Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass | NEW YORK UNIVERSITY (US) | 2010-09-14 | — | — | US | disclosed |
| US-7335655-B2 | 8-heteroaryl xanthine adenosine A2B receptor antagonists | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| WO-2007095161-A2 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS ASSOCIATED WITH INCREASED BONE TURNOVER AND OSTEOPENIA | NEW YORK UNIVERSITY (US) | 2007-08-23 | — | — | WO | disclosed |
| US-20070191279-A1 | Methods and compositions for treating disorders associated with increased bone turnover and osteopenia | CRONSTEIN BRUCE N | 2007-08-16 | — | — | US | disclosed |
| US-7205403-B2 | 8-Heteroaryl xanthine adenosine A2B receptor antagonists | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-5733916-A | RESPIRATORY SYSTEM DISORDERS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0793406-A1 | Process for producing multilayer wiring boards | TOKYO OHKA KOGYO CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| EP-0755254-A1 | PREVENTION AND TREATMENT OF ISCHEMIA-REPERFUSION AND ENDOTOXIN-RELATED INJURY USING ADENOSINE AND PURINO RECEPTOR ANTAGONISTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1997-01-29 | — | — | EP | disclosed |
| US-5504090-A | Compositions and methods for the prevention and treatment of ischemia-reperfusion organ injury | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1996-04-02 | — | — | US | disclosed |
| WO-1995026728-A1 | PREVENTION AND TREATMENT OF ISCHEMIA-REPERFUSION AND ENDOTOXIN-RELATED INJURY USING ADENOSINE AND PURINO RECEPTOR ANTAGONISTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1995-10-12 | — | — | WO | disclosed |
| US-5453426-A | Sulfur-containing xanthine derivatives as adenosine antagonists | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1995-09-26 | — | — | US | disclosed |
| US-4968672-A | DRUG DELIVERY; DIURETICS, KIDNEY DISORDERS, HYPOTENSIVE AGENTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1990-11-06 | — | — | US | disclosed |
| WO-1990012797-A1 | SULFER-CONTAINING XANTHINE DERIVATIVES AS ADENOSIN ANTAGONISTS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (US) | 1990-11-01 | — | — | WO | disclosed |
| US-4741818-A | COMPLEXES | LEARONAL, INC. (US) | 1988-05-03 | — | — | US | disclosed |
| EP-0225422-A1 | Alkaline baths and methods for electrodeposition of palladium and palladium alloys | LeaRonal, Inc. (US) | 1987-06-16 | — | — | EP | disclosed |