Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3B
The experimentally established mechanism targets of Av-101. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 3/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.40 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Av-101 SCHEMBL18742668 | 1.00 | KMO (0.51) | KMOHIF1AKDM4ETDP1ABL1 | |
| Av-101 SCHEMBL727370 | 1.00 | KMO (0.51) | KMOHIF1AKDM4ETDP1ABL1 | |
| Av-101 SCHEMBL30216614 | 1.00 | KMO (0.51) | KMOHIF1AKDM4ETDP1ABL1 | |
| Av-101 SCHEMBL5286788 | 1.00 | KMO (0.51) | KMOHIF1AKDM4ETDP1ABL1 | |
| Av-101 SCHEMBL30733184 | 1.00 | KMO (0.51) | KMOHIF1AKDM4ETDP1ABL1 | |
| Av-101 SCHEMBL16098317 | 0.93 | KMO (0.46) | KMOHIF1AKDM4ETDP1ABL1 | |
| SCHEMBL8397345 | 0.88 | KMO (0.51) | KMOHIF1AKDM4ETDP1GRIK1 | |
| SCHEMBL30852448 | 0.88 | KMO (0.51) | KMOHIF1AKDM4ETDP1GRIK1 | |
| SCHEMBL8397341 | 0.88 | KMO (0.51) | KMOHIF1AKDM4ETDP1GRIK1 | |
| SCHEMBL30852441 | 0.88 | KMO (0.51) | KMOHIF1AKDM4ETDP1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120019060-A | Compounds and their use for filtering ultraviolet and/or high-energy visible light | 索利奥美公司 | 2025-05-16 | — | — | CN | claimed |
| EP-4587007-A2 | COMPOUNDS AND THEIR USE IN FILTERING ULTRAVIOLET AND/OR HIGH-ENERGY VISIBLE LIGHT | Soliome, Inc. (US) | 2025-07-23 | — | — | EP | disclosed |
| CN-120019060-A | Compounds and their use for filtering ultraviolet and/or high-energy visible light | 索利奥美公司 | 2025-05-16 | — | — | CN | disclosed |
| WO-2024059119-A2 | COMPOUNDS AND THEIR USE IN FILTERING ULTRAVIOLET AND/OR HIGH-ENERGY VISIBLE LIGHT | SOLIOME, INC. (US) | 2024-03-21 | — | — | WO | disclosed |