Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | FADS1 | O60427 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967428 | 1.00 | KMO (0.51) | KMOKDM4EHIF1ATDP1NOS2 | |
| SCHEMBL30852448 | 1.00 | KMO (0.51) | KMOKDM4EHIF1ATDP1NOS2 | |
| SCHEMBL8397345 | 1.00 | KMO (0.51) | KMOKDM4EHIF1ATDP1NOS2 | |
| SCHEMBL30852441 | 1.00 | KMO (0.51) | KMOKDM4EHIF1ATDP1NOS2 | |
| SCHEMBL8396747 | 0.98 | KMO (0.50) | KMOKDM4EHIF1ATDP1NOS2 | |
| SCHEMBL8396761 | 0.98 | KMO (0.50) | KMOKDM4EHIF1ATDP1NOS2 | |
| Av-101 SCHEMBL5286788 | 0.88 | KMO (0.51) | KMOKDM4EHIF1ATDP1SLC1A3 | |
| Av-101 SCHEMBL727370 | 0.88 | KMO (0.51) | KMOKDM4EHIF1ATDP1SLC1A3 | |
| Av-101 SCHEMBL30852264 | 0.88 | KMO (0.51) | KMOKDM4EHIF1ATDP1SLC1A3 | |
| Av-101 SCHEMBL18742668 | 0.88 | KMO (0.51) | KMOKDM4EHIF1ATDP1SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663899-B1 | SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS | UNIV MARYLAND (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0919538-A1 | Substituted kynurenines, a process for their preparation, and use as medicaments | THE UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 1999-06-02 | — | — | EP | disclosed |
| US-5786508-A | ENZYME INHIBITOR; COGNITION ACTIVATOR | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-07-28 | — | — | US | disclosed |
| EP-0663899-A4 | SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS. | UNIV MARYLAND (US) | 1996-01-17 | — | — | EP | disclosed |
| CN-1113386-A | Substituted kynurenines, a process for their preparation, and use as medicaments | UNIV MARYLAND (US) | 1995-12-13 | — | — | CN | disclosed |
| EP-0663899-A1 | SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS | THE UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 1995-07-26 | — | — | EP | disclosed |
| WO-1995004714-A1 | SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS | UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 1995-02-16 | — | — | WO | disclosed |