Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.35 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581198 | 1.00 | HRH3 (0.37) | HRH3TRPM8FPR1FPR2PSEN1 | |
| SCHEMBL3075597 | 1.00 | HRH3 (0.37) | HRH3TRPM8FPR1FPR2PSEN1 | |
| SCHEMBL582599 | 0.97 | HRH3 (0.35) | HRH3TRPM8FPR1FPR2PSEN1 | |
| SCHEMBL582600 | 0.97 | HRH3 (0.35) | HRH3TRPM8FPR1FPR2PSEN1 | |
| SCHEMBL3075881 | 0.86 | ALDH1A1 (0.39) | HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL3081049 | 0.86 | ALDH1A1 (0.39) | HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL581482 | 0.86 | ALDH1A1 (0.39) | HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL581335 | 0.85 | HRH3 (0.41) | HRH3TRPM8FPR1FPR2PSEN1 | |
| SCHEMBL586566 | 0.85 | HRH3 (0.41) | HRH3TRPM8FPR1FPR2PSEN1 | |
| SCHEMBL3075467 | 0.83 | KMT2A (0.43) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415378-B2 | Isoxazol-3(2H)-one analogs as therapeutic agents | ASTRAZENECA AB (SE) | 2013-04-09 | — | — | US | disclosed |
| US-20100261755-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261755-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | NR4A3, CBR3, OXER1 | HRH3 394/4885TRPM8 2189/4885FPR1 763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.