Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | BMX | P51813 | 3/20 | 0.36 |
| ▸ | ITK | Q08881 | 3/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | LCK | P06239 | 3/20 | 0.32 |
| ▸ | LYN | P07948 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29333515 | 1.00 | BTK (0.36) | BTKEGFRBMXITKCCNC | |
| SCHEMBL29333484 | 0.90 | BTK (0.38) | BTKEGFRBMXITKCCNC | |
| SCHEMBL29333504 | 0.89 | HCRTR1 (0.41) | BTKEGFRBMXITKCCNC | |
| SCHEMBL29333391 | 0.88 | HCRTR1 (0.39) | BTKEGFRBMXITKCCNC | |
| SCHEMBL31008584 | 0.88 | HCRTR1 (0.39) | BTKEGFRBMXITKCCNC | |
| SCHEMBL30855178 | 0.87 | BTK (0.36) | BTKEGFRBMXITKCCNC | |
| SCHEMBL29333566 | 0.87 | BTK (0.36) | BTKEGFRBMXITKCCNC | |
| SCHEMBL29333505 | 0.87 | FGFR4 (0.37) | BTKEGFRBMXITKCCNC | |
| SCHEMBL31008576 | 0.86 | CCNC (0.34) | BTKEGFRBMXITKCCNC | |
| SCHEMBL29335758 | 0.86 | CCNC (0.34) | BTKEGFRBMXITKCCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594308-A1 | N-ACRYLOYLMORPHOLINE DERIVATIVES AS KEAP1 MODULATORS AND USES THEREOF | Vividion Therapeutics, Inc. (US) | 2025-08-06 | — | — | EP | disclosed |
| US-20250228866-A1 | CRYSTALLINE FORM OF (R)-1-(3-(3-(4-AMINOPYRIMIDIN-2-YL)-5-CHLOROPHENYL)MORPHOLINO)PROP-2-EN-1-ONE | VIVIDION THERAPEUTICS, INC. | 2025-07-17 | — | — | US | disclosed |
| US-20250228866-A1 | CRYSTALLINE FORM OF (R)-1-(3-(3-(4-AMINOPYRIMIDIN-2-YL)-5-CHLOROPHENYL)MORPHOLINO)PROP-2-EN-1-ONE | VIVIDION THERAPEUTICS, INC. | 2025-07-17 | — | — | US | disclosed |
| US-20240226114-A1 | INHIBITORS AND USES THEREOF | VIVIDION THERAPEUTICS, INC. | 2024-07-11 | — | — | US | disclosed |
| WO-2024073587-A1 | N-ACRYLOYLMORPHOLINE DERIVATIVES AS KEAP1 MODULATORS AND USES THEREOF | VIVIDION THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250228866-A1 | CRYSTALLINE FORM OF (R)-1-(3-(3-(4-AMINOPYRIMIDIN-2-YL)-5-CHLOROPHENYL)MORPHOLINO)PROP-2-EN-1-ONE | KEAP1, NCOR1, NFE2L2 | BTK 4735/4885EGFR 3739/4885BMX 3851/4885 |
| US-20240226114-A1 | INHIBITORS AND USES THEREOF | KEAP1, NQO1, NFE2L2 | BTK 3290/4885EGFR 4004/4885BMX 1404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.