Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 14/20 | 1.00 |
| ▸ | MKNK2 | Q9HBH9 | 14/20 | 1.00 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.67 |
| ▸ | F7 | P08709 | 1/20 | 0.63 |
| ▸ | F3 | P13726 | 1/20 | 0.63 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.63 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.63 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.63 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.63 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.63 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.63 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.63 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606654 | 1.00 | MKNK1 (1.00) | MKNK1MKNK2CHEK2F7F3 | |
| SCHEMBL27521530 | 0.86 | MKNK1 (0.74) | MKNK1MKNK2CHEK2F7F3 | |
| SCHEMBL27605181 | 0.85 | MKNK1 (0.76) | MKNK1MKNK2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4508905 | 0.84 | MKNK1 (0.71) | MKNK1MKNK2CHEK2F7F3 | |
| SCHEMBL208351 | 0.83 | MKNK1 (1.00) | MKNK1MKNK2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL29788154 | 0.83 | MKNK1 (1.00) | MKNK1MKNK2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28305277 | 0.83 | MKNK1 (0.71) | MKNK1MKNK2CHEK2F7F3 | |
| SCHEMBL13188346 | 0.82 | MKNK1 (0.77) | MKNK1MKNK2CHEK2F7F3 | |
| SCHEMBL608617 | 0.82 | KMO (0.73) | MKNK1MKNK2CHEK2F7F3 | |
| SCHEMBL30108236 | 0.82 | MKNK1 (0.77) | MKNK1MKNK2CHEK2F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594294-A1 | DOPAMINE D3/D2 RECEPTOR PARTIAL AGONISTS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024072930-A1 | DOPAMINE D3/D2 RECEPTOR PARTIAL AGONISTS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2024-04-04 | — | — | WO | disclosed |