Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | NOS1 | P29475 | 4/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | TDO2 | P48775 | 8/20 | 0.45 |
| ▸ | IDO1 | P14902 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14718665 | 0.80 | PIM3 (0.50) | NOS1PIM3PIM1TDO2IDO1 | |
| SCHEMBL31217276 | 0.78 | CYP1A2 (0.51) | CYP1A2NOS1PIM3PIM1TDO2 | |
| SCHEMBL30410207 | 0.78 | IDO1 (0.47) | CYP1A2NOS1TDO2IDO1 | |
| SCHEMBL19948646 | 0.78 | IDO1 (0.47) | CYP1A2NOS1TDO2IDO1 | |
| SCHEMBL4400129 | 0.78 | NOS1 (0.57) | NOS1PIM3PIM1TDO2IDO1 | |
| SCHEMBL1250107 | 0.78 | NOS1 (0.57) | NOS1PIM3PIM1TDO2IDO1 | |
| SCHEMBL21271929 | 0.78 | NOS1 (0.61) | CYP1A2NOS1PIM3PIM1TDO2 | |
| SCHEMBL2571809 | 0.74 | NOS1 (0.61) | CYP1A2NOS1PIM3PIM1TDO2 | |
| SCHEMBL21196262 | 0.73 | IDO1 (0.47) | NOS1TDO2IDO1 | |
| SCHEMBL21379129 | 0.73 | TDO2 (0.43) | CYP1A2NOS1PIM3TDO2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120152713-A | Tricyclic aryl derivatives and compositions and methods thereof | 昂胜医疗科技公司 | 2025-06-13 | — | — | CN | disclosed |
| EP-4561562-A2 | TRICYCLIC ARYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | Ensem Therapeutics, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| WO-2024026128-A2 | TRICYCLIC ARYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | ENSEM THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |