Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | FPR1 | P21462 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30860074 | 0.87 | PTGDR2 (0.50) | PTGDR2NPBWR1AKR1C3 | |
| SCHEMBL30860079 | 0.84 | NPBWR1 (0.48) | PTGDR2NPBWR1AKR1C3 | |
| SCHEMBL30859877 | 0.81 | NPBWR1 (0.46) | PTGDR2NPBWR1AKR1C3 | |
| SCHEMBL31464912 | 0.79 | NPBWR1 (0.46) | NPBWR1AKR1C3 | |
| SCHEMBL25225321 | 0.79 | MAPT (0.44) | ALDH1A1MAPTKDM4ETHRBFPR1 | |
| SCHEMBL24739013 | 0.79 | NPBWR1 (0.52) | MAPTNPBWR1 | |
| SCHEMBL27165200 | 0.76 | MAPT (0.44) | ALDH1A1MAPTKDM4EHSD17B10KMT2A | |
| SCHEMBL24739563 | 0.76 | MAPT (0.35) | ALDH1A1MAPTTHRBPTGDR2NPBWR1 | |
| SCHEMBL24739469 | 0.76 | MAPT (0.35) | ALDH1A1MAPTTHRBPTGDR2NPBWR1 | |
| SCHEMBL24739192 | 0.75 | MAPT (0.34) | ALDH1A1MAPTTHRBPTGDR2NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594314-A1 | PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS | Azkarra Therapeutics, Inc. (US) | 2025-08-06 | — | — | EP | disclosed |
| CN-119968364-A | Pyridazin-3 (2H) -one and pyridin-2 (1H) -one PARP inhibitor compounds | 阿兹卡拉疗法公司 | 2025-05-09 | — | — | CN | disclosed |
| WO-2024073133-A1 | PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS | AZKARRA THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |