Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 6/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 5/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30859849 | 0.86 | TIPARP (0.40) | TIPARPGLAKDM4EALDH1A1GAA | |
| SCHEMBL28819986 | 0.83 | TIPARP (0.44) | TIPARPGLAKDM4EALDH1A1GAA | |
| SCHEMBL15633341 | 0.79 | TIPARP (0.40) | TIPARPALDH1A1GAAARIDO1 | |
| SCHEMBL24968908 | 0.75 | TIPARP (0.43) | TIPARPARIDO1 | |
| SCHEMBL8478938 | 0.75 | BACE1 (0.40) | GLAKDM4EALDH1A1GAAHPGD | |
| SCHEMBL24968328 | 0.75 | ALDH1A1 (0.47) | TIPARPGLAKDM4EALDH1A1HPGD | |
| SCHEMBL30851298 | 0.74 | TIPARP (0.42) | TIPARPARIDO1NOTUM | |
| SCHEMBL30507321 | 0.74 | TIPARP (0.43) | TIPARPIDO1NOTUM | |
| SCHEMBL16231863 | 0.74 | HCAR2 (0.42) | GLAKDM4EALDH1A1GAAMAPT | |
| SCHEMBL15633366 | 0.73 | NOTUM (0.43) | TIPARPGLAKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594314-A1 | PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS | Azkarra Therapeutics, Inc. (US) | 2025-08-06 | — | — | EP | disclosed |
| CN-119968364-A | Pyridazin-3 (2H) -one and pyridin-2 (1H) -one PARP inhibitor compounds | 阿兹卡拉疗法公司 | 2025-05-09 | — | — | CN | disclosed |
| WO-2024073133-A1 | PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS | AZKARRA THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |