Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | INSR | P06213 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | NPM1 | P06748 | 1/20 | 0.41 |
| ▸ | FES | P07332 | 1/20 | 0.41 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30860746 | 0.90 | EGFR (0.54) | EGFRMETBTKROS1FER | |
| SCHEMBL30860740 | 0.90 | EGFR (0.54) | EGFRMETBTKINSRIGF1R | |
| SCHEMBL30860346 | 0.90 | EGFR (0.64) | EGFRMETBTKINSRIGF1R | |
| SCHEMBL30860290 | 0.88 | EGFR (0.53) | EGFRMETBTKINSRIGF1R | |
| SCHEMBL30860753 | 0.86 | EGFR (0.50) | EGFRMETBTKINSRIGF1R | |
| SCHEMBL30860281 | 0.85 | EGFR (0.51) | EGFRMETBTKINSRIGF1R | |
| SCHEMBL30860759 | 0.84 | EGFR (0.56) | EGFRMETBTKROS1FER | |
| SCHEMBL30860273 | 0.84 | EGFR (0.53) | EGFRMETBTKROS1FER | |
| SCHEMBL25001448 | 0.82 | EGFR (0.58) | EGFRMETBTKINSRIGF1R | |
| SCHEMBL30860330 | 0.82 | EGFR (0.66) | EGFRMETBTKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024072075-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2024-04-04 | — | — | WO | claimed |
| WO-2024072075-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2024-04-04 | — | — | WO | disclosed |