Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | RARB | P10826 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | RARA | P10276 | 1/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | CETP | P11597 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | TACR2 | P21452 | 2/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | SHBG | P04278 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL20791912 | 1.00 | ALDH1A1 (0.63) | ALDH1A1KCNH2MAPTRXFP1RARB | |
| Bicarbonate SCHEMBL27383749 | 1.00 | ALDH1A1 (0.63) | ALDH1A1KCNH2MAPTRXFP1RARB | |
| Bicarbonate SCHEMBL27383089 | 1.00 | ALDH1A1 (0.63) | ALDH1A1KCNH2MAPTRXFP1RARB | |
| Bicarbonate SCHEMBL27451151 | 1.00 | ALDH1A1 (0.63) | ALDH1A1KCNH2MAPTRXFP1RARB | |
| Bicarbonate SCHEMBL20791904 | 0.98 | ALDH1A1 (0.61) | ALDH1A1KCNH2MAPTRXFP1RARB | |
| Acetic Acid SCHEMBL27798118 | 0.94 | ALDH1A1 (0.61) | ALDH1A1KCNH2MAPTRXFP1RARB | |
| Acetic Acid SCHEMBL27621705 | 0.94 | ALDH1A1 (0.61) | ALDH1A1KCNH2MAPTRXFP1RARB | |
| Hydrogen Peroxide SCHEMBL15515419 | 0.94 | KCNH2 (0.69) | ALDH1A1KCNH2CETPESR1ADRA2A | |
| Acetic Acid SCHEMBL8583606 | 0.92 | ALDH1A1 (0.63) | ALDH1A1KCNH2MAPTRXFP1RARB | |
| Butylbenzyl SCHEMBL27660882 | 0.91 | ALDH1A1 (0.64) | ALDH1A1MAPTRXFP1RARBCETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795207-B2 | Lipopeptide compositions | MERLION PHARMACEUTICALS GMBH (DE) | 2010-09-14 | — | — | US | disclosed |
| US-20070219124-A1 | Lipopeptide compositions | COMBINATURE BIOPHARM AG (DE) | 2007-09-20 | — | — | US | disclosed |
| CN-1308370-C | Method for end-capping polycarbonate resins and composition for use in same | GEN ELECTRIC (US) | 2007-04-04 | — | — | CN | disclosed |
| CN-1646599-A | Method for end-capping polycarbonate resins and compositions useful therein | GEN ELECTRIC (US) | 2005-07-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219124-A1 | Lipopeptide compositions | NOD2, IAPP, PTMS | ALDH1A1 4861/4885KCNH2 4626/4885MAPT 3729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.