Nanaomycin

Nanaomycin

SCHEMBL30861963

CC1OC(CC(=O)O)CC2=C1C(=O)c1c(O)cccc1C2=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 1.00
DNMT3B Q9UBC3 1/20 1.00
PAX8 Q06710 1/20 1.00
AKT1 P31749 3/20 0.75
CTH P32929 1/20 0.75
TDP2 O95551 1/20 0.52
TCF4 P15884 1/20 0.49
CTNNB1 P35222 1/20 0.49
IDO1 P14902 2/20 0.45
STAT3 P40763 4/20 0.41
MAOA P21397 2/20 0.40
TSHR P16473 3/20 0.39
HSD17B10 Q99714 3/20 0.39
ALDH1A1 P00352 2/20 0.39
LMNA P02545 2/20 0.39
MAPT P10636 2/20 0.39
HPGD P15428 2/20 0.39
ALOX15 P16050 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
TDP1 Q9NUW8 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nanaomycin SCHEMBL20473784 1.00 HSP90AA1 (1.00) HSP90AA1DNMT3BPAX8AKT1CTH
Nanaomycin SCHEMBL30778402 1.00 HSP90AA1 (1.00) HSP90AA1DNMT3BPAX8AKT1CTH
Nanafrocin SCHEMBL2111571 1.00 HSP90AA1 (1.00) HSP90AA1DNMT3BPAX8AKT1CTH
Nanaomycin SCHEMBL18567076 1.00 HSP90AA1 (1.00) HSP90AA1DNMT3BPAX8AKT1CTH
SCHEMBL30193239 0.90 DNMT3B (0.82) HSP90AA1DNMT3BPAX8AKT1CTH
SCHEMBL29927569 0.88 DNMT3B (0.78) HSP90AA1DNMT3BPAX8AKT1CTH
SCHEMBL28398864 0.87 DNMT3B (0.77) HSP90AA1DNMT3BPAX8AKT1CTH
SCHEMBL20144857 0.86 DNMT3B (0.75) HSP90AA1DNMT3BPAX8AKT1CTH
SCHEMBL1177648 0.80 DNMT3B (0.66) HSP90AA1DNMT3BPAX8AKT1CTH
SCHEMBL20442857 0.80 DNMT3B (0.66) HSP90AA1DNMT3BPAX8AKT1CTH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4157458-B1 TRIARYLPYRIDINE COMPOUNDS AND USE THEREOF FOR TREATING CANCER INST NAT SANTE RECH MED (FR) 2024-04-17 EP claimed