SCHEMBL30861998

SCHEMBL30861998

Nc1nc(Cl)nc(Cl)c1F

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.35
ALOX15 P16050 1/20 0.35
TSHR P16473 1/20 0.35
KHK P50053 1/20 0.32
HTT P42858 1/20 0.31
CDK1 P06493 1/20 0.31
CSNK1A1 P48729 1/20 0.30
CLK4 Q9HAZ1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20267103 1.00 ALDH1A1 (0.35) ALDH1A1ALOX15TSHRKHKHTT
SCHEMBL219104 0.80 ALDH1A1 (0.47) ALDH1A1ALOX15TSHR
SCHEMBL9160684 0.79 HSP90B1 (0.33) KHK
SCHEMBL20267115 0.75 KHK (0.31) KHK
SCHEMBL115474 0.75 HTT (0.33) ALDH1A1KHKHTT
SCHEMBL18913381 0.75 CDK1 (0.33) ALDH1A1ALOX15TSHRCDK1
SCHEMBL3444583 0.72 ALDH1A1 (0.39) ALDH1A1ALOX15TSHRHTTCDK1
SCHEMBL5635013 0.72 ALDH1A1 (0.39) ALDH1A1ALOX15TSHR
SCHEMBL1182747 0.72 ALDH1A1 (0.39) ALDH1A1ALOX15TSHRHTTCDK1
SCHEMBL30696398 0.70 KMT2A (0.42) ALDH1A1ALOX15TSHRHTTCDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117924258-A Pyridone compound derivative and application thereof 复旦大学 2024-04-26 CN disclosed