Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SLC6A19 | Q695T7 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.40 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30435177 | 0.82 | — | — | |
| SCHEMBL50668 | 0.82 | — | — | |
| Ethylene Glycol SCHEMBL5831465 | 0.80 | ALDH1A1 (0.50) | HSD17B3ALDH1A1PKMSLC6A19BACE1 | |
| Styrene SCHEMBL28475247 | 0.80 | ALDH1A1 (0.61) | ALDH1A1CYP1A2CYP2C19MAPTHTT | |
| SCHEMBL8715895 | 0.80 | ALDH1A1 (0.58) | HSD17B3ALDH1A1SLC6A19BACE1CYP1A2 | |
| Styrene SCHEMBL11873214 | 0.75 | ALDH1A1 (0.54) | ALDH1A1CYP2C19TDP1 | |
| SCHEMBL12686013 | 0.74 | EGFR (0.43) | HSD17B3ALDH1A1TGM2MAOAMAOB | |
| Methyl Alcohol SCHEMBL27537082 | 0.74 | ALDH1A1 (0.47) | HSD17B3ALDH1A1SLC6A19CYP1A2CYP2C19 | |
| Bromobenzene SCHEMBL27713764 | 0.73 | ALDH1A1 (0.55) | ALDH1A1PARP1MAOAMAOBTDP1 | |
| Vinyl Ether SCHEMBL5832123 | 0.73 | ALDH1A1 (0.43) | HSD17B3ALDH1A1PKMSLC6A19BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117858877-A | C-linked inhibitors of ENL/AF9 YEATS | 桥梁药品有限公司 | 2024-04-09 | — | — | CN | disclosed |