Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27083368 | 1.00 | PDE3B (0.63) | PDE3BPDE3ASMN1; SMN2LMNAHTT | |
| SCHEMBL27083348 | 0.91 | PDE3B (0.63) | PDE3BPDE3ASMN1; SMN2LMNAHTT | |
| SCHEMBL30864989 | 0.91 | PDE3B (0.63) | PDE3BPDE3ASMN1; SMN2LMNAHTT | |
| SCHEMBL12633839 | 0.79 | KMT2A (0.72) | LMNAKMT2AMEN1PKMALDH1A1 | |
| SCHEMBL27083360 | 0.78 | SMN1; SMN2 (0.73) | SMN1; SMN2LMNAHTTTSHRRAB9A | |
| SCHEMBL30864992 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| SCHEMBL27083327 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| SCHEMBL30865005 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| SCHEMBL27083318 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| SCHEMBL27083363 | 0.74 | SMN1; SMN2 (0.82) | SMN1; SMN2LMNAHTTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043384-A1 | INHIBITORS OF PU.1 FOR THE TREATMENT OF DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2024-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240043384-A1 | INHIBITORS OF PU.1 FOR THE TREATMENT OF DISEASE | CREBBP, JUN, SP1 | PDE3B 3463/4885PDE3A 3040/4885SMN1; SMN2 763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.