Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | ATF1 | P18846 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018647 | 0.91 | PDK1 (0.45) | PDK1NTRK1CHEK2 | |
| SCHEMBL30865908 | 0.91 | PDK1 (0.45) | PDK1NTRK1CHEK2 | |
| SCHEMBL1017764 | 0.87 | PDK1 (0.45) | TSHRTRPM8PDK1NTRK1NR1H4 | |
| SCHEMBL27191559 | 0.82 | PDK1 (0.51) | TSHRGAAPDK1 | |
| SCHEMBL1017890 | 0.82 | CHEK2 (0.39) | NTRK1CHEK2 | |
| SCHEMBL27191561 | 0.80 | PDK1 (0.51) | TSHRPDK1CHEK2 | |
| SCHEMBL30865885 | 0.79 | PDK1 (0.50) | PDK1NTRK1 | |
| SCHEMBL17783745 | 0.79 | PDK1 (0.50) | PDK1NTRK1 | |
| SCHEMBL1018375 | 0.77 | PDK1 (0.52) | PDK1NTRK1 | |
| SCHEMBL30865896 | 0.77 | NNMT (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240116872-A1 | PYRIDYL INHIBITORS FOR HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2024-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240116872-A1 | PYRIDYL INHIBITORS FOR HEDGEHOG SIGNALLING | SHH, GLI1, SMO | TSHR 453/4885TRPM8 3527/4885GAA 4693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.