Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 6/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18818255 | 1.00 | RPS6KA5 (0.43) | RPS6KA5HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL18289975 | 1.00 | RPS6KA5 (0.43) | RPS6KA5HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL28908346 | 0.87 | ADORA3 (0.45) | ADORA3ADORA2BJAK2JAK1JAK3 | |
| SCHEMBL18285473 | 0.81 | JAK2 (0.40) | RPS6KA5HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL29737109 | 0.80 | RXFP1 (0.34) | — | |
| SCHEMBL29614483 | 0.79 | TLR7 (0.41) | RPS6KA5HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL25616564 | 0.79 | CHRM2 (0.46) | KCNH2JAK2JAK1JAK3TLR7 | |
| SCHEMBL30111811 | 0.76 | BTK (0.39) | BTKJAK2JAK1JAK3TLR7 | |
| SCHEMBL18285554 | 0.76 | BTK (0.45) | BTKJAK2JAK1JAK3 | |
| SCHEMBL18285551 | 0.76 | BTK (0.45) | BTKJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113149983-B | Tyrosine kinase inhibitors | 普林斯匹亚生物制药公司 | 2024-03-29 | — | — | CN | disclosed |