Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.40 |
| ▸ | JAK3 | P52333 | 10/20 | 0.40 |
| ▸ | JAK1 | P23458 | 10/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18818255 | 0.81 | RPS6KA5 (0.43) | JAK2JAK3JAK1HTR3EHTR3B | |
| SCHEMBL30866992 | 0.81 | RPS6KA5 (0.43) | JAK2JAK3JAK1HTR3EHTR3B | |
| SCHEMBL18289975 | 0.81 | RPS6KA5 (0.43) | JAK2JAK3JAK1HTR3EHTR3B | |
| SCHEMBL18843035 | 0.74 | BTK (0.58) | BTK | |
| SCHEMBL30970924 | 0.73 | EGFR (0.56) | JAK2JAK3JAK1BTK | |
| SCHEMBL2104869 | 0.72 | JAK2 (0.79) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL29614483 | 0.72 | TLR7 (0.41) | HTR3EHTR3BHTR2BHTR3ATMEM97 | |
| Hydrochloric Acid SCHEMBL2104724 | 0.71 | JAK2 (0.77) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL6584642 | 0.71 | CHRM2 (0.61) | MAPK1 | |
| Hydrochloric Acid SCHEMBL11203042 | 0.70 | CHRM2 (0.60) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303334-A1 | TYROSINE KINASE INHIBITORS | Principia Biopharma Inc. (US) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016196840-A1 | TYROSINE KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2016-12-08 | — | — | WO | disclosed |